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Comparison of hair thyroid hormones between first‐episode and recurrent patients with depression in female C hinese
Author(s) -
Yang Xiao,
Sun Guizhi,
Wei Jinxue,
Huang Bin,
Zhao Liansheng,
Wang Yingcheng,
Zhou Bo,
Tao Li,
Ma Xiaohong
Publication year - 2016
Publication title -
asia‐pacific psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.654
H-Index - 21
eISSN - 1758-5872
pISSN - 1758-5864
DOI - 10.1111/appy.12223
Subject(s) - hamd , major depressive disorder , depression (economics) , medicine , anxiety , bipolar disorder , hormone , endocrinology , psychology , psychiatry , amygdala , lithium (medication) , economics , macroeconomics
Objective The aim of this study was to compare hair thyroid hormone ( TH ) levels among first‐episode patients with major depressive disorder ( F ‐ MDD ), recurrent patients with major depressive disorder ( R ‐ MDD ) and healthy controls ( HC ). Methods The Hamilton Depression Scale ( HAMD ) and Hamilton Anxiety Scale ( HAMA ) were used to evaluate the clinical symptoms of patients. Electrochemiluminescence immunoassay was used to measure the hair TH levels. We compared the differences in hair TH levels among F ‐ MDD patients, R‐ MDD patients, and HC . Results Before the disease episode, hair T 3 levels differed significantly between F ‐ MDD patients and HC . In the disease episode, hair T 3 levels differed significantly between F ‐ MDD or R ‐ MDD patients and HC ; and hair T 4 levels differed significantly between R ‐ MDD patients and HC . Hair T 3 levels significantly negative correlated with HAMD scores in F ‐ MDD patients. Conclusions Our findings suggested that disease duration of recurring episodes of depression may influence hair TH levels.