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−141 C insertion/deletion polymorphism of the dopamine D 2 receptor gene is associated with schizophrenia in C hinese H an population: Evidence from an ethnic group‐specific meta‐analysis
Author(s) -
Zhao Xiaofeng,
Huang Yinglin,
Chen Kaiyuan,
Li Duolu,
Han Chao,
Kan Quancheng
Publication year - 2016
Publication title -
asia‐pacific psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.654
H-Index - 21
eISSN - 1758-5872
pISSN - 1758-5864
DOI - 10.1111/appy.12206
Subject(s) - odds ratio , genotype , genetics , single nucleotide polymorphism , polymorphism (computer science) , biology , gene , medicine
Accumulate evidence has implicated dopamine D 2 receptor gene polymorphisms in the etiology of schizophrenia. A single nucleotide polymorphism, −141 C insertion/deletion ( I ns/ D el) (rs1799732), in the promoter region of the dopamine D 2 receptor gene has been linked to schizophrenia; however, the data are inconclusive. This study investigated whether the −141 C polymorphism is associated with the risk of schizophrenia in different ethnic groups by performing a meta‐analysis. A total of 24 case–control studies examining the association between −141 C I ns/ D el polymorphism and schizophrenia were identified according to established inclusion criteria. Significant association was revealed between −141 C I ns/ D el polymorphism and schizophrenia risk in dominant genetic model ( I ns/ I ns + I ns/ D el versus D el/ D el) (odds ratio = 0.33, 95% confidence interval = 0.14–0.81, z = 2.41, P = 0.02) in C hinese H an but not in C aucasian, J apanese or I ndia populations. Our results indicate that −141 C I ns/ D el polymorphism might be a susceptibility factor for schizophrenia in C hinese H an population.