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Lack of genetic association of 5‐ HTR 2 A 102 T/C and ‐1438 A/G polymorphisms with T ourette syndrome in a family‐based association study in a C hinese H an population
Author(s) -
Xu Longqiang,
Zheng Lanlan,
Ma Jianhua,
Su Nailun,
Liu Yujun,
Ma Xu,
Zhang Xinhua,
Liu Shiguo
Publication year - 2016
Publication title -
asia‐pacific psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.654
H-Index - 21
eISSN - 1758-5872
pISSN - 1758-5864
DOI - 10.1111/appy.12185
Subject(s) - transmission disequilibrium test , confidence interval , genetics , haplotype , genotype , allele , polymorphism (computer science) , population , linkage disequilibrium , biology , medicine , gene , environmental health
Our purpose is to investigate whether polymorphisms of 102 T/C and ‐1438 A/G in 5 HTR 2 A are associated with T ourette syndrome ( TS ) in C hinese H an population. Methods A total of 178 TS trios were recruited in this study. After the allelic and genotypic distributions of two polymorphisms were genotyped using polymerase chain reaction and restriction fragment length polymorphism (PCR‐RFLP), we compared their genetic distributions with what is expected with H ardy– W einberg to explore whether there might be an association of these polymorphisms with TS by haplotype relative risk ( HRR ) and transmission disequilibrium test ( TDT ) statistics. Results Our results showed that no significant associations were found between the HTR2A 102 T/C and ‐1438 A/G polymorphisms and TS (for HTR2A 102 T/C : TDT = 2.041, df = 1, P = 0.175; HRR = 1.468, χ 2 = 1.905, P = 0.168, 95% confidence interval: 0.850–2.535; for HTR2A : ‐1438A/G, TDT = 0.093, df = 1, P = 0.819; HRR = 0.965, χ 2 = 0.018, P = 0.894, 95% confidence interval: 0.574–1.624). Discussion Our study suggested that the HTR2A 102 T/C and ‐1438 A/G polymorphisms may not be associated with susceptibility to TS , and thus do not play a major role in the development of TS in the C hinese H an population. However, these results need to be confirmed in a larger sample collected from different populations.