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Evaluating the association between CACNA1C rs1006737 and schizophrenia risk: A meta‐analysis
Author(s) -
Jiang Hongyan,
Qiao Fei,
Li Zongfang,
Zhang Yaping,
Cheng Yuqi,
Xu Xiufeng,
Yu Li
Publication year - 2015
Publication title -
asia‐pacific psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.654
H-Index - 21
eISSN - 1758-5872
pISSN - 1758-5864
DOI - 10.1111/appy.12173
Subject(s) - single nucleotide polymorphism , odds ratio , meta analysis , snp , allele , genetic association , genetics , schizophrenia (object oriented programming) , locus (genetics) , biology , medicine , genotype , psychiatry , gene
Genetic analyses including genome‐wide association studies have reported an intronic single nucleotide polymorphism ( SNP ) rs1006737 in CACNA1C gene (encoded calcium channel, voltage‐dependent, L type, alpha 1 C subunit) as a risk factor for schizophrenia in European populations. The replications in other ethnic populations such as E ast A sians have also been conducted, but the results were inconsistent, either likely due to the limited sample size of single study or genetic heterogeneity between continental populations on this locus. Methods We performed a comprehensive meta‐analysis of all available samples from existing studies of E ast A sian populations, including a total of 9,432 cases and 10,661 controls, to further confirm whether CACNA1C rs1006737 is an authentic risk SNP for schizophrenia in East Asian populations. Results Our results revealed a significant association between rs1006737 and schizophrenia (allelic model, P = 4.39 × 10 −6 , pooled odds ratio [ OR ] = 1.20), and the results were much strengthened when the E uropean and E ast A sian samples were combined together ( P = 2.40 × 10 −17 , pooled OR = 1.12). There is no significant heterogeneity or publication bias between individual studies, and removal of any single study still remained significant associations between rs1006737 and schizophrenia. Discussion Our results further confirmed that rs1006737 should be categorized as an authentic risk SNP for schizophrenia in the general populations.