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Significant association of close homologue of L 1 gene polymorphism rs2272522 with schizophrenia in Q atar
Author(s) -
Shaltout Taher E.,
Alali Khalid Abdulla,
Bushra Sumbul,
Alkaseri Aisha Mubarak,
Jose Elizabeth Divya,
AlKhainji Mozza,
Saleh Randah,
Salama Dahir Amany,
Shaltout Hany,
AlAbdullah Maged,
Rizk Nasser M.
Publication year - 2013
Publication title -
asia‐pacific psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.654
H-Index - 21
eISSN - 1758-5872
pISSN - 1758-5864
DOI - 10.1111/appy.12014
Subject(s) - single nucleotide polymorphism , linkage disequilibrium , genotype , locus (genetics) , genetics , genetic association , genotyping , allele , biology , population , snp , gene , medicine , environmental health
Previous reports have found that polymorphisms in the close homologue of L 1 ( CHL1 ) gene located on chromosome 3p26 are associated with schizophrenia among different ethnic populations. The aim of this study was to examine the associations of single nucleotides polymorphisms ( SNPs ) of the CHL1 gene locus, including rs2055314 ( C/T ), rs2272522 ( C/T ) and rs331894 ( A/G ), with schizophrenia in the Q atari population. Methods An association case control study was carried out on 86 Q atari schizophrenic patients from the P sychiatry H ospital, H ammed M edical C orporation, Q atar and 88 Q atari unrelated, healthy, control subjects. Schizophrenia was diagnosed according to the D iagnostic and S tatistical M anual of M ental D isorders – F ourth E dition ( DSM‐IV ) criteria for schizophrenia by two independent psychiatrists. Genotyping of the SNPs rs2055314 ( C/T ), rs2272522 ( C/T ) and rs331894 ( A/G ) was conducted using the 5′ nuclease assay with the TaqMan MGB probe and an ABI 7500. Results Individuals with the rs2272522 TT genotype had approximately 4.2 times greater risk of schizophrenia compared to individuals with the CC genotype ( OR = 4.21; 95% CI : 1.12–15.53; P = 0.047). In addition, individuals carrying a T allele of the rs2272522 SNP had a significantly increased risk of schizophrenia (1.78 times) among the population ( P = 0.028). SNPs rs2055314 and rs331894 had no significant association with schizophrenia. Pairwise linkage disequilibrium ( LD ) between the three polymorphisms was modest in the schizophrenic group. Discussion The rs2272522 polymorphism was found to exhibit a highly significant association with schizophrenia in the Q atari population. This finding supports the hypothesis that cell adhesion molecules may be involved in the etiology of this disease among Q atari patients.