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Impact of various culture conditions on ex vivo expansion of polyclonal T cells for adoptive immunotherapy
Author(s) -
Ghaffari Sasan,
TorabiRahvar Monireh,
Omidkhoda Azadeh,
Ahmadbeigi Naser
Publication year - 2019
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12981
Subject(s) - adoptive immunotherapy , immunotherapy , ex vivo , polyclonal antibodies , t cell , adoptive cell transfer , cell therapy , immunology , cancer immunotherapy , cancer research , biology , microbiology and biotechnology , medicine , in vivo , stem cell , immune system , antigen , genetics
Currently, adoptive immunotherapy is considered as one of the leading treatments in cancer. Successful adoptive immunotherapy depends on producing large numbers of desired T cells ex vivo for infusion. This requires an effective protocol for maximum functional T‐cell expansion while keeping the time and costs to a minimum. Current T‐cell expansion protocols are diverse in their methodology, and a universal protocol of expansion is wanting. Also, new findings regarding T‐cell biology, signaling, and activation have reshaped the strategies of T‐cell propagation over the years, introducing new ways to expand T cells. Here, we reviewed different conditions for blood‐derived polyclonal T‐cell expansion so as to elucidate the influential factors of T‐cell expansion and their efficacy.