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Cytopathological features of secretory carcinoma of salivary glands and ancillary techniques in its diagnostics: impact of new Milan system for reporting salivary gland cytopathology
Author(s) -
Miesbauerová Markéta,
Tommola Satu,
Šteiner Petr,
Baněčková Martina,
Skálová Alena,
Kholová Ivana
Publication year - 2019
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12950
Subject(s) - cytopathology , salivary gland , pathology , etv6 , acinic cell carcinoma , malignancy , mammaglobin , eosinophilic , immunohistochemistry , cytology , fine needle aspiration , immunocytochemistry , biology , medicine , chromosomal translocation , mucoepidermoid carcinoma , biopsy , cancer , biochemistry , breast cancer , gene
Secretory carcinoma ( SC ) of salivary glands is a newly described low‐grade malignancy characterized by the presence of ETV 6 rearrangement. Only a few cases and very small series with cytomorphology were reported so far. Six cases of fine‐needle aspirations ( FNA s) from afterward histologically, immunohistochemically and genetically confirmed SC s were retrieved from the archives of the authors. Ancillary immunocytochemistry ( ICC ) and translocation detection were performed on cell blocks ( CB s). All aspirates were sufficiently cellular and cells were arranged in more or less cohesive groups with only mild nuclear polymorphism. The cytoplasm was eosinophilic, granulated and vacuolated, especially in CB s. Secretory material within the microcystic spaces was periodic acid‐Schiff ( PAS ) positive. Triple positivity of immunomarkers S‐100 protein, mammaglobin and vimentin was present. The proliferation index was low. Ancillary techniques suggested the possibility of SC in a few cytology cases; nevertheless, the final diagnosis was based on histomorphology, immunohistochemistry and genetics. The SC of salivary glands is detectable pre‐operatively using ICC and genetics. The presence of the diagnostic ETV 6 rearrangement increases the accuracy of FNA to the maximum. According to the Milan system, cases genetically not confirmed should be categorized as Suspicious for Malignancy or Salivary Gland Neoplasm of Uncertain Malignant Potential ( SUMP ), both requiring surgery.