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Cellular expression of CD markers in immune thrombocytopenic purpura: implications for prognosis
Author(s) -
Behzad Masumeh Maleki,
Asnafi Ali Amin,
Jalalifar Mohammad Ali,
Moghtadaei Mostafa,
Jaseb Kaveh,
Saki Najmaldin
Publication year - 2018
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12853
Subject(s) - immune system , thrombocytopenic purpura , platelet , flow cytometry , immunology , medicine , gastroenterology
Immune thrombocytopenic purpura ( ITP ) is an autoimmune bleeding disorder associated with platelet destruction. Abnormalities in frequency and function of different immune cells can play a crucial role in this disease. The aim of this study was to evaluate the prognostic value of CD markers’ expressions by immune cells in ITP . Peripheral blood samples were collected from 25 ITP patients before and after treatment. The expression of CD markers was evaluated by flow cytometry technique. The expression of CD 38 and CD 56 was significantly lower before treatment than after it (p = 0.025 and p = 0.036, respectively). Furthermore, a positive correlation was found between CD 38 expression with platelet count before (r = 0.496, p = 0.012) and after treatment (r = 0.404, p = 0.045). No significant relationship was found between this marker and platelet count while CD 4 expression was higher before treatment than after it (p = 0.002). In conclusion, CD 38 may have independent prognostic value in ITP and we suggest that it can be a prognostic marker for this disease.