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Expression of CD markers' in immune thrombocytopenic purpura: prognostic approaches
Author(s) -
Behzad Masumeh Maleki,
Asnafi Ali Amin,
Jaseb Kaveh,
Jalali Far Mohammad Ali,
Saki Najmaldin
Publication year - 2017
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12755
Subject(s) - thrombocytopenic purpura , autoantibody , immune system , immunology , platelet , medicine , lymphocyte , platelet membrane glycoprotein , antibody
Immune Thrombocytopenic Purpura ( ITP ) is a common autoimmune bleeding disorder characterized by a reduction in peripheral blood platelet counts. In this disease, autoantibodies (Auto‐Abs) are produced against platelet GPII b/ GPIII a by B cells, which require interaction with T cells. In this review, the importance of B and T lymphocytes in ITP prognosis has been studied. Relevant literature was identified by a PubMed search (1990–2016) of English‐language papers using the terms B and T lymphocyte, platelet, CD markers and immune thrombocytopenic purpura. T and B lymphocytes are the main immune cells in the body. Defective function causes disrupted balance of different subgroups of lymphocytes, and abnormal expression of surface markers of these cells results in self‐tolerance dysfunction, as well as induction of Auto‐Abs against platelet glycoproteins ( PG ). Given the role of B and T cells in production of autoantibodies against PG , it can be stated that the detection of changes in CD markers' expression in these cells can be a good approach for assessing prognosis in ITP patients.