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Clinicopathological study of lip cancer: a retrospective hospital‐based study in Taiwan
Author(s) -
Tseng HuiWen,
Liou HueiHan,
Tsai KuoWang,
Ger LuoPing,
Shiue YowLing
Publication year - 2017
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12751
Subject(s) - medicine , hazard ratio , gastroenterology , proportional hazards model , cancer , odds ratio , stage (stratigraphy) , lymph node , carcinoma , basal cell , retrospective cohort study , basal cell carcinoma , logistic regression , confidence interval , biology , paleontology
To evaluate the clinicopathological characteristics, high‐risk lifestyle factors ( HRLF : chronic exposure to sun, betel quid, alcohol, and tobacco), and prognostic factors of lip cancer. The hospital records of patients with pathologically confirmed lip squamous cell carcinoma ( LSCC , n = 112) and lip basal cell carcinoma ( LBCC , n = 21) were reviewed. Differences in clinicopathological characteristics between LSCC and LBCC , upper and lower lip, and status of second primary tumors were compared by chi‐square test and logistic regression. The prognostic factors for LSCC were analyzed by Cox regression. Compared with LBCC patients, LSCC patients were men‐predominant (p < 0.001), had younger ages at onset (p < 0.001), and higher rates of lower lips involvement (p < 0.001) and HRLF s. Patients with second primary tumors were highly associated with lower lip cancer involvement (adjusted odds ratio = 2.91, p = 0.03). Patients with lower lip cancer had more HRLF s with an increasing linear trend (p = 0.004). The poorer prognostic factors of LSCC for disease‐specific survival were advanced stage III / IV [crude hazard ratio ( CHR ) = 11.16, p < 0.001], tumor dimension >4 cm ( CHR = 8.19, p = 0.006), lymph node involvement ( CHR = 11.48, p < 0.001), and recurrence ( CHR = 3.96, p = 0.01); whereas for disease‐free survival were moderately to poorly differentiated LSCC ( CHR = 4.97, p = 0.002) and alcohol consumption ( CHR = 3.13, p = 0.04). LSCC and lower lip cancer were highly associated with HRLF s.