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NUT carcinoma presenting in the palate – a case report
Author(s) -
Bjornstrup Libana Raffoul,
Reibel Jesper,
Kiss Katalin,
Schioedt Morten
Publication year - 2017
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12710
Subject(s) - head and neck , nut , medicine , immunohistochemistry , pathology , carcinoma , head and neck cancer , cancer , surgery , structural engineering , engineering
NUT carcinomas ( NC ) are rare and aggressive tumours characterized by chromosomal rearrangements of the gene encoding for nuclear protein of the testis ( NUT ) located on chromosome 15q14. This article presents a case of a 60‐year‐old woman diagnosed with NC presenting as a fast growing primary tumour in the right palate. Further evaluation revealed a tumour mass in the lungs and widespread metastases. A review of the literature did not reveal earlier cases presenting in the palate. In order to improve early diagnosis it is suggested to perform immunohistochemical testing for NUT in all poorly differentiated carcinomas without glandular differentiation arising in the chest, and head and neck ( Clin Cancer Res, 18, 2012, 5773).