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Prognostic value of p21‐activated kinase 4 in resected pancreatic cancer
Author(s) -
Park Sehhoon,
Kim Jin Won,
Kim Haeryoung,
Kim JiWon,
Kim Yu Jung,
Lee KeunWook,
Kim Jee Hyun,
Kim Jai Hwan,
Hwang JinHyeok,
Choi Young Rok,
Cho Jai Young,
Yoon YooSeok,
Han HoSeong
Publication year - 2017
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12705
Subject(s) - medicine , hazard ratio , pancreatic cancer , oncology , immunohistochemistry , pancreatectomy , gemcitabine , univariate analysis , gastroenterology , adenocarcinoma , lymph node , cancer , biomarker , confidence interval , pathology , pancreas , biology , multivariate analysis , biochemistry
Resectable pancreatic cancer has a high recurrence rate after curative surgery. Biomarkers are needed for distinguishing patients who may benefit from curative resection. In this study, we sought to analyze the prognostic value of p21‐activated kinase 1 ( PAK 1), p21‐activated kinase 4 ( PAK 4), human equilibrative nucleoside transporter 1 ( hENT 1), and thymidylate synthase ( TS ) in surgically resected pancreatic ductal adenocarcinomas. A total of 160 pancreatic cancer patients who underwent surgery with curative intent were retrospectively reviewed. Tissue microarrays were constructed and immunohistochemical stains were performed for PAK 1, PAK 4, hENT 1, and TS . The absence of PAK 4 expression in pancreatic adenocarcinomas was associated with poorer histologic differentiation (p < 0.001), shorter overall survival [hazard ratio ( HR ) = 2.86, 95% confidence interval ( CI ) 1.43–5.71; p = 0.003], and disease‐free survival ( HR = 2.29, 95% CI: 1.11–4.74; p = 0.025) on univariate analyses. In addition, more frequent venous invasion and lymph node metastases were seen in PAK 4‐negative tumors although not statistically significant. PAK 1, hENT 1, and TS expression status did not have significant influences on patient survival. In conclusion, PAK 4 of the markers tested in this study may be a potential prognostic biomarker for pancreatic adenocarcinomas.