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Orthopaedic biofilm infections
Author(s) -
Zimmerli Werner,
Sendi Parham
Publication year - 2017
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12687
Subject(s) - joint infections , periprosthetic , osteomyelitis , biofilm , medicine , antibiotics , antimicrobial , bone infection , implant , microbiology and biotechnology , surgery , biology , arthroplasty , bacteria , genetics
Many infections of the musculoskeletal system are biofilm infections that develop on non‐living surfaces. Microorganisms adhere either on dead bone (sequesters) or implants. As a rule for a curative concept, chronic osteomyelitis or implant‐associated bone infection must be treated with a combination of surgery and antimicrobial therapy. If an implant is kept in place, or a new device is implanted before complete healing of infection, a biofilm‐active antibiotic should be used. Rifamycins are active against biofilms of staphylococci, and fluoroquinolones against those of Gram‐negative bacilli. In this review, the management of chronic osteomyelitis, periprosthetic joint infection and implant‐associated osteomyelitis of long bones is presented.