Toll‐like receptor‐2 Arg753Gln and Arg677Trp polymorphisms and susceptibility to pulmonary and peritoneal tuberculosis

Recent evidence suggests that toll‐like receptor‐2 ( TLR 2) is important for host defense against Mycobacterium tuberculosis ( MTB ). TLR 2 polymorphisms have shown significant impact on susceptibility or resistance to tuberculosis ( TB ). This case–control study aims to determine the influence of TLR 2 (Arg753Gln and Arg677Trp) polymorphisms on the susceptibility to develop pulmonary or peritoneal TB . Genotyping of TLR 2 (Arg753Gln and Arg677Trp) polymorphisms was carried out on 52 patients with pulmonary TB , 44 patients with peritoneal TB , and 50 healthy controls using polymerase chain reaction‐restriction fragment length polymorphism ( PCR ‐ RFLP ). There was a significant association between the GA genotype (heterozygous mutant) of TLR 2 Arg753Gln polymorphism and the risk of infection with pulmonary TB (p = 0.003, OR = 4.83) and TB peritonitis (p = 0.003, OR = 6.2). Differences in the genotype frequencies of TLR 2 Arg677Trp polymorphisms between patients with pulmonary or peritoneal TB and healthy controls were not detected. GA 753 TLR 2 polymorphism may play a role in the susceptibility to pulmonary and peritoneal TB infection. Further studies on a large number of ethnically diverse patient cohorts may help to confirm the possible effect of these polymorphisms on the susceptibility to pulmonary and peritoneal TB .