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Biofilms and host response – helpful or harmful
Author(s) -
Moser Claus,
Pedersen Hannah Trøstrup,
Lerche Christian Johann,
Kolpen Mette,
Line Laura,
Thomsen Kim,
Høiby Niels,
Jensen Peter Østrup
Publication year - 2017
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12674
Subject(s) - biofilm , obligate , host response , microbiology and biotechnology , host (biology) , cystic fibrosis , biology , immune system , immunology , innate immune system , endocarditis , medicine , bacteria , ecology , genetics , surgery
Biofilm infections are one of the modern medical world's greatest challenges. Probably, all non‐obligate intracellular bacteria and fungi can establish biofilms. In addition, there are numerous biofilm‐related infections, both foreign body‐related and non‐foreign body‐related. Although biofilm infections can present in numerous ways, one common feature is involvement of the host response with significant impact on the course. A special characteristic is the synergy of the innate and the acquired immune responses for the induced pathology. Here, we review the impact of the host response for the course of biofilm infections, with special focus on cystic fibrosis, chronic wounds and infective endocarditis.