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Retracted: Curcumin inhibits the survival and metastasis of prostate cancer cells via the Notch‐1 signaling pathway
Author(s) -
Yang Jingzhe,
Wang Chengli,
Zhang Zhijie,
Chen Xiaojun,
Jia Yusen,
Wang Bin,
Kong Tao
Publication year - 2017
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12650
Subject(s) - du145 , curcumin , prostate cancer , cancer research , notch signaling pathway , metastasis , signal transduction , notch 1 , cancer , cancer cell , mmp2 , medicine , biology , microbiology and biotechnology , pharmacology , lncap
Prostate cancer is one of the most common malignancies in men, and it urgently demands precise interventions that target the signaling pathways implicated in its initiation, progression, and metastasis. The Notch‐1 signaling pathway is closely associated with the pathophysiology of prostate cancer. This study investigated the antitumor effects and mechanisms of curcumin, which is a well‐known natural compound from curcuminoids, in prostate cancer cells. Viability, proliferation, and migration were analyzed in two prostate cancer cell lines, DU 145 and PC 3, after curcumin treatment. Whether the Notch‐1 signaling pathway is involved in the antitumor effects of curcumin was examined. Curcumin inhibited the survival and proliferation of PC 3 and DU 145 cells in a dose‐ and time‐dependent manner and inhibited DU 145 migration. Curcumin did not affect the expression of Notch‐1 or its active product NICD , but it did inhibit the expression of MT 1‐ MMP and MMP 2 proteins in DU 145 cells. We found that curcumin inhibited the DNA ‐binding ability of NICD in DU 145 cells. In conclusion, curcumin inhibited the survival and metastasis of prostate cancer cells via the Notch‐1 signaling pathway.