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Changes in ventilatory capacity and pulmonary gas exchange during systemic and pulmonary inflammation in humans
Author(s) -
Hartmann Jacob P.,
Mottelson Mathis N.,
Berg Ronan M. G.,
Plovsing Ronni R.
Publication year - 2017
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12626
Subject(s) - systemic inflammation , medicine , inflammation , cardiology , pulmonary diffusing capacity , intensive care medicine , lung , lung function , diffusing capacity
The exact mechanism linking the systemic inflammatory response associated with sepsis to changes in lung function remains to be determined. In a human experimental model of inflammation, we investigated how acute systemic and local pulmonary inflammation affects ventilatory capacity and pulmonary gas exchange. Fifteen volunteers received Escherichia coli lipopolysaccharide ( LPS ) intravenously or endobronchially on two different study days. Blood samples were obtained hourly (t = 0–8 h) and spirometry was performed at baseline and after 8 h. Both interventions decreased ventilatory capacity compared to baseline (p < 0.01), and this was more pronounced after intravenous (forced expiratory volume in 1‐s, FEV 1 ; 0.6 L/12% reduction) compared to endobronchial ( FEV 1 ; 0.32 L/7% reduction) administration (p < 0.05). Furthermore, the alveolar‐arterial oxygen difference increased after intravenous but not after endobronchial endotoxin. These findings indicate that pulmonary gas exchange is impaired to a greater extent during endotoxin‐induced systemic inflammation than during endotoxin‐induced local pulmonary inflammation.