z-logo
Premium
Prevalence of systemic autoimmune rheumatic diseases and clinical significance of ANA profile: data from a tertiary hospital in S hanghai, C hina
Author(s) -
Yang Zaixing,
Ren Yingpeng,
Liu Donghong,
Lin Feng,
Liang Yan
Publication year - 2016
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12564
Subject(s) - medicine , polymyositis , mixed connective tissue disease , anti nuclear antibody , dermatomyositis , rheumatoid arthritis , autoantibody , ankylosing spondylitis , extractable nuclear antigens , clinical significance , antibody , immunology , dermatology
It is necessary and useful to explore prevalence of various systemic autoimmune rheumatic diseases ( SARD s) in patients with suspicion of having SARD s and to characterize antinuclear antibodies ( ANA ) profile for identifying different populations ( SARD s and non‐ SARD s). A total of 5024 consecutive patients with available medical records were investigated, whose sera had been tested for ANA profile, including ANA , anti‐ds DNA and anti‐extractable nuclear antigen ( ENA ) antibodies, between 31 January 2012 and 26 March 2014. Only 594 (11.8%) patients were diagnosed with SARD s of those suspected with SARD s. The prevalence of systemic lupus erythematosus ( SLE ) was highest (3.2%), followed by rheumatoid arthritis ( RA ) (2.5%), primary Sjögren's syndrome ( pSS ) (1.7%), ankylosing spondylitis ( AS ) (1.5%), etc. Of females, SLE also showed the highest prevalence (6%), while of males, AS showed the highest prevalence (1.9%). The prevalence of most SARD s was closely associated with age, except mixed connective tissue disease ( MCTD ), and the variation characteristics among different age groups were different among various SARD s. The prevalence of ANA was significantly increased in most SARD patients [especially in SLE , systemic sclerosis ( SS c) and MCTD ]. For anti‐ ENA antibodies, in contrast to some autoantibodies associated with multiple SARD s (e.g. anti‐ SSA , SSB , nRNP ), others were relatively specific for certain diseases, such as anti‐ds DNA , Sm, histone, nucleosome and Rib‐P for SLE , anti‐ SCL ‐70 for SS c and anti‐Jo‐1 for polymyositis/dermatomyositis ( PM / DM ). Of note, ANA profile appeared to be of little significance for AS , ANCA ‐associated vasculitis ( AAV ), polymyalgia rheumatic ( PMR ), adult‐onset Still's disease ( ASD ) and Behcet's disease ( BD ). The younger were more likely to have the presence of anti‐ds DNA , Sm, histone or Rib‐P for SLE , and anti‐ SSA for RA or MCTD . No significant differences for frequencies of ANA and anti‐ ENA autoantibodies were found between sexes in most SARD s, with the exception of RA and AS . The present study suggests that, of patients with SARD s‐like clinical manifestations, the proportion of those with true SARDS is small, for most of whom tests for autoantibodies are necessary and useful to help make a prompt and precise diagnosis.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here