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Gene polymorphism in DNA repair genes XRCC 1 and XRCC 6 and association with colorectal cancer in Swedish patients
Author(s) -
Dimberg Jan,
Skarstedt Marita,
Slind Olsen Renate,
Andersson Roland E.,
Matussek Andreas
Publication year - 2016
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12563
Subject(s) - colorectal cancer , single nucleotide polymorphism , genotype , snp , allele , odds ratio , confidence interval , dna repair , medicine , cancer , gene , biology , oncology , genetics
The DNA repair genes XRCC 1 and XRCC 6 have been proposed to participate in the pathological process of cancer by modulating the DNA repair capacity. This study evaluated the susceptibility of the single‐nucleotide polymorphisms ( SNP s) XRCC 1 (rs25487, G > A) and XRCC 6 (rs2267437, C > G) to colorectal cancer ( CRC ) and their association with clinical parameters in Swedish patients with CRC . Using the TaqMan system, these SNP s were screened in 452 patients and 464 controls. No significant difference in genotype distribution was found between the patients and controls, or any significant association with cancer‐specific or disease‐free survival in patients. However, we showed that the carriers of allele A in XRCC 1 (rs25487, G > A) were connected with a higher risk of disseminated CRC (Odds Ratio = 1.64; 95% Confidence Interval = 1.12–2.41, p = 0.012).