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Aberrant NEAT 1 expression is associated with clinical outcome in high grade glioma patients
Author(s) -
He Chengbiao,
Jiang Bing,
Ma Jianrong,
Li Qiaoyu
Publication year - 2016
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12480
Subject(s) - glioma , medicine , outcome (game theory) , expression (computer science) , biology , oncology , cancer research , pathology , computer science , mathematics , mathematical economics , programming language
Long noncoding RNA (lnc RNA ) NEAT 1 has been reported to play critical roles in various human tumor entities and related to the survival of patients with malignancies. However, little is known about the role of lnc RNA NEAT 1 in glioma patients. The aim of this study was to investigate the expression of NEAT 1 in human glioma and its correlation with clinicopathological features and prognosis in human glioma; we analyzed the relationship of lncRNA NEAT1 expression with clinicopathological characteristics and prognosis in glioma patients. In our results, the relative level of NEAT 1 expression was higher in cancer tissues compared with adjacent noncancerous tissues (p < 0.001). High NEAT 1 expression was observed to be closely correlated with larger tumor size (p = 0.023), higher WHO grade (p = 0.005), and recurrence (p = 0.011). Kaplan–Meier curves showed that patients with high NEAT 1 expression showed unfavorable overall survival ( OS ) than the low NEAT 1 expression group (p = 0.002). Multivariate analysis results revealed that NEAT 1 overexpression was an independent prognostic factor for OS in addition to postoperative chemoradiotherapy and WHO grade. Moreover, high NEAT 1 expression in patients with stage III ~ IV disease and postoperative chemoradiotherapy conferred unfavorable OS (stage III ~ IV p = 0.002, postoperative chemoradiotherapy p = 0.000). This study supports NEAT 1 as a potential prognostic predictor with its high expression in cancer tissues and its association with carcinogenesis and progression in glioma.