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Analysis of iron acquisition and storage‐related genes in clinical and non‐clinical strains of Yersinia enterocolitica biovar 1A
Author(s) -
Kanaujia Pawan Kumar,
Bajaj Priyanka,
Virdi Jugsharan Singh
Publication year - 2015
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12425
Subject(s) - biovar , yersinia enterocolitica , biology , microbiology and biotechnology , gene , yersinia , bacteria , genetics
Possession of mechanisms for iron acquisition and its storage enhances the ability of the bacteria to survive in the iron‐limiting environment of the host. In this study, 81 strains of Yersinia enterocolitica biovar 1A isolated from various clinical ( n = 51) and non‐clinical ( n = 30) sources were investigated for the presence of the genes related to iron acquisition and storage. Important genes which were present in more than 85% of the strains included hasA , foxA , bfr, bfd, ftnA , and hmsT as well as the fhu CDB , fep BDGC fesfepA, feo AB , yfu ABCD , hem PRSTUV , and hms HFRS gene clusters. Majority of these genes is being reported for the first time in biovar 1A strains and showed significant homology with genes present in the known pathogenic biovars of Y. enterocolitica . However, no significant difference was observed in the distribution of iron acquisition and storage‐related genes among clinical and non‐clinical biovar 1A strains. Thus, it may be suggested that the presence of iron acquisition and storage‐related genes per se might not be responsible for the supposedly better ability of clinical biovar 1A strains to cause infections in humans. However, in the backdrop of this data, the need to undertake functional studies are highly recommended.