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Clinicopathological features of plasmablastic multiple myeloma: a population‐based cohort
Author(s) -
Møller Hanne E. H.,
Preiss Birgitte S.,
Pedersen Per,
Kristensen Ida B.,
Hansen Charlotte T.,
Frederiksen Mikael,
Abildgaard Niels,
Møller Michael B.
Publication year - 2015
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12411
Subject(s) - pathology , multiple myeloma , cytogenetics , karyotype , fluorescence in situ hybridization , population , molecular cytogenetics , univariate analysis , biology , medicine , oncology , multivariate analysis , chromosome , genetics , environmental health , gene
Multiple myeloma ( MM ) is a common malignant hematological disease displaying considerable heterogeneity. Historical data indicate a prognostic significance of plasmablastic morphology, proliferation, and adverse cytogenetics, but there is little knowledge on the degree of interdependency of these parameters. The aim of this study was to study the degree of overlap between these variables. In a consecutive population‐based cohort of 194 untreated MM patients, morphology, and proliferation index, using immunohistochemical double staining for K i‐67 and CD 138, was analyzed. In addition, cytogenetic changes were studied by karyotyping and fluorescence in situ hybridization ( FISH ). Plasmablastic morphology correlated with unfavorable clinical features, high proliferation index, high percentage of plasma cell infiltration in the bone marrow, abnormal karyotype, and del(13q) detected by karyotyping, which indicates that plasmablastic morphology reflects advanced and highly proliferative disease. However, plasmablastic morphology did not correlate with established adverse prognostic cytogenetics identified by FISH , for example, t(4;14), t(14;16) and del(17p).