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A clinicopathological analysis of KISS 1 and KISS 1R expression in colorectal cancer
Author(s) -
Kostakis Ioannis D.,
Agrogiannis George,
Vaiopoulos Aristeidis G.,
Mylona Eleni,
Patsouris Efstratios,
Kouraklis Gregory,
Koutsilieris Michael
Publication year - 2015
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12397
Subject(s) - kiss (tnc) , colorectal cancer , cancer , medicine , computer science , computer network
Kisspeptins, the products of the KISS 1 gene have tumor suppressing and antimetastatic properties. We aimed to study KISS 1 and KISS 1R expression in colorectal cancer. We analyzed KISS 1 and KISS 1R expression using immunohistochemistry and image analysis in normal and malignant tissue samples from 111 patients with colorectal adenocarcinoma. KISS 1 expression was much higher in the normal than in the malignant colonic mucosa. Regarding malignant tissues, KISS 1 levels were higher in larger tumors, in stage III and IV cancers, in cancers with lymph node metastasis and in tumors located in the distal part of the large intestine. Patients with greater KISS 1 levels had worse prognosis. No KISS 1R expression was detected in normal or malignant tissues or in liver metastases. KISS 1 expression is reduced during the malignant transformation of the colonic mucosa. However, larger and advanced colorectal cancers express more KISS 1, without reaching the former normal levels, and increased KISS 1 levels are associated with worse prognosis. Finally, neither the normal nor the malignant colonic epithelial cells produce KISS 1R.