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Bacterial vaccines in chronic obstructive pulmonary disease: effects on clinical outcomes and cytokine levels
Author(s) -
Ruso Salvador,
Marco Francisco M.,
MartínezCarbonell Juan A.,
Carratalá José A.
Publication year - 2015
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12386
Subject(s) - medicine , copd , exacerbation , bronchiectasis , cytokine , immunology , pathogenesis , inflammation , lung , disease , gastroenterology
Chronic obstructive pulmonary disease ( COPD ) is a major cause of mortality and morbidity worldwide. Exacerbation episodes impair lung function leading to disease progression. Levels of inflammation markers correlate with disease severity. Bacterial immunomodulators have shown a beneficial effect in COPD , improving symptoms and reducing the rate of exacerbations. This is an observational prospective study on 30 patients diagnosed with bronchiectasis and COPD , who received bacterial autogenous vaccine for 12 months. The rate of exacerbation, severity of symptoms and lung function were studied at baseline and after treatment. In addition, plasma levels CRP , IL 6, IL 8, and TNF α were measured. After treatment we found a reduction in mean acute respiratory infections and signs of lung disease. Acute phase proteins IL 6 and CRP increased in blood and IL 8 decreased. These changes may be related to the repeated injection of inactivated bacteria. Given the implication of these factors in the pathogenesis of COPD , particularly the production of IL 8, the causes and consequences of cytokine modulation by bacterial vaccines should be investigated. Vaccination with autogenous vaccines for 1 year can produce a significant clinical improvement in COPD patients, reducing the frequency of exacerbations associated to changes in the profile of markers of inflammation.