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Secretion, blood levels and cutaneous expression of TL 1A in psoriasis patients
Author(s) -
Pedersen Anders Elm,
Schmidt Esben Gjerløff Wedebye,
Sørensen Jesper Freddie,
Faber Carsten,
Nielsen Boye Schnack,
Holmstrøm Kim,
Omland Silje Haukali,
Tougaard Peter,
Skov Søren,
Bang Bo
Publication year - 2015
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12385
Subject(s) - psoriasis , secretion , medicine , immunology , dermatology , endocrinology
TL 1A is a TNF ‐like cytokine which has been shown to co‐stimulate TH 1 and TH 17 responses during chronic inflammation. The expression of this novel cytokine has been investigated in inflammatory disorders like rheumatoid arthritis and inflammatory bowel disease, but little is known about expression and induction in psoriasis. Indeed, the pathogenesis in psoriasis is still not fully understood and it is speculated that cytokines other than TNF ‐α are important in subsets of patients. Also, for patients with severe disease that are treated with systemic anti‐ TNF ‐α blockade, novel candidates to be used as disease and response biomarkers are of high interest. Here, we demonstrate TL 1A expression in biopsies from psoriatic lesions. Also, we investigated spontaneous and induced TL 1A secretion from PBMC s and blood levels from a cohort of psoriasis patients. Here, increased spontaneous secretion from PBMC s was observed as compared to healthy controls and a small subset of patients had highly elevated TL 1A in the blood. Interestingly, activation of PBMC s with various cytokines showed a decreased sensitivity for TL 1A activation in psoriasis patients compared to healthy controls. TL 1A levels in blood and biopsies could not be correlated with disease activity with this patient cohort. Thus, additional large‐scale studies are warranted to investigate TL 1A as a biomarker.