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Nucleophosmin overexpression is associated with poor survival in astrocytoma
Author(s) -
Kuo YenHsin,
Chen YiTing,
Tsai HungPei,
Chai CheeYin,
Kwan AijLie
Publication year - 2015
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12381
Subject(s) - nucleophosmin , stat5 , janus kinase , cancer research , medicine , janus kinase 2 , signal transduction , oncology , biology , receptor , biochemistry , myeloid leukemia
The multiple functions of the protein nucleophosmin ( NPM ) include the regulation and balance of cell growth, proliferation, and apoptosis. Many cancers have suspected associations with overexpression of NPM or with mutation of the NPM gene. Although NPM and anaplastic lymphoma kinase fusion proteins are known to be related to the Janus Kinase/Signal Transduction and Activator of Transcription ( JAK / STAT ) signaling pathway, the relationships of NPM , JAK 2, and STAT 5 to astrocytoma remain unclear. Therefore, this study performed histochemical analyses of expressions of NPM , p‐ JAK 2, and STAT 5B proteins in patients with astrocytoma. The results showed that high NPM expression was significantly associated with high tumor grade (p = 0.000), old age (p = 0.000), low Karnofsky Performance Scale ( KPS ) score (p = 0.000), and tumor recurrence (p = 0.045). High p‐ JAK 2 expression was significantly associated with old age (p = 0.000), high tumor grade (p = 0.000), low KPS score (p = 0.000), and tumor recurrence (p = 0.036). Expression of STAT 5B was significantly correlated with tumor grade (p = 0.018) and KPS score (p = 0.002). High expressions of NPM , p‐ JAK 2, and STAT 5B were associated with a short survival time (p = 0.035, 0.003 and 0.002, respectively). In multivariable analysis, STAT 5B expression was a significant predictor of survival time (p = 0.003). In conclusion, NPM and p‐ JAK 2/ STAT 5B may have important roles in tumor progression, and STAT 5B is an independent prognostic marker of astrocytoma.