Premium
Colorectal adenocarcinoma with mucinous component: relation of MMP ‐13, EGFR , and E ‐cadherin expressions to clinicopathological features and prognosis
Author(s) -
Foda Abd AlRahman Mohammad,
ElHawary Amira Kamal,
Aziz Azza Abdel
Publication year - 2015
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12379
Subject(s) - perineural invasion , medicine , adenocarcinoma , colorectal cancer , immunohistochemistry , colorectal adenocarcinoma , tissue microarray , cadherin , univariate analysis , mucinous carcinoma , oncology , pathology , gastroenterology , cancer , biology , multivariate analysis , genetics , cell
The aim of this study was to compare colorectal adenocarcinoma with mucinous component, ordinary adenocarcinoma ( OA ) and mucinous adenocarcinoma ( MA ) regarding clinicopathological parameters, survival, EGFR , MMP ‐13, and E ‐cadherin. We studied tumor tissue specimens from 28 patients with adenocarcinoma with mucinous component, 47 with OA , and 56 with MA , who underwent radical surgery from J anuary 2007 to J anuary 2012 at the G astroenterology C entre, M ansoura U niversity, E gypt. High density manual tissue microarrays were constructed and immunohistochemistry for EGFR , MMP ‐13, and E ‐cadherin was done. Colorectal adenocarcinoma with mucinous component ( AWMC ) was significantly associated with more perineural invasion, lower EGFR , and MMP ‐13 expressions than OA , with no difference in E ‐cadherin expression. Conversely, only microscopic abscess formation was significantly more with colorectal AWMC than MC with no difference in EGFR , MMP ‐13 and E ‐cadherin expression between both groups. Colorectal AWMC showed a better survival than MA with no difference with OA . In a univariate analysis, EGFR , MMP ‐13, and E ‐cadherin expressions did not show a significant impact on disease‐free or overall survival in patients with colorectal AWMC . Colorectal AWMC remains a vague entity that resembles OA in some clinicopathological and molecular respects as well as MA .