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Association of TAP 1 and TAP 2 genes with susceptibility to pulmonary tuberculosis in Koreans
Author(s) -
Roh Eun Youn,
Yoon Jong Hyun,
Shin Sue,
Song Eun Young,
Park Myoung Hee
Publication year - 2015
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12373
Subject(s) - genetic predisposition , tuberculosis , immunology , medicine , pathology , disease
Tuberculosis remains an important public health problem in Koreans. However, very few studies have reported on the genetic factors associated with TB susceptibility in Koreans. The aim of this study was to elucidate the genetic factors associated with susceptibility to pulmonary tuberculosis ( PTB ). We investigated the transporter associated with antigen processing –1 ( TAP 1) and TAP 2 gene polymorphisms in 160 Korean PTB patients (categorized according to extent of lesion and TB medication history) and 210 controls. TAP 2*C/E frequency was significantly increased in the PTB (p c = 0.004, OR = 2.28). TAP 2*Bky2/C/E were enriched in the retreated, far‐advanced and total PTB compared with the controls (p c = 0.015, OR = 3.27; p c = 0.019, OR = 2.56; p c = 2.8 × 10 −4 , OR = 2.42, respectively). In the comparison of TAP 2 gene with the DRB 1*08:03 , which is associated with TAP 2*Bky2 and PTB in Koreans, we demonstrated the hierarchy of these association factors. TAP 2*C/E is independent factors as strong as DRB 1*08:03 , and TAP 2*C/E interacts with DRB 1*08:03 , resulting in a striking combined association. Our results suggest that TAP 2 gene has an association with PTB susceptibility, the extent of the lesion or recurrence. These associations are independent from and additive with DRB 1*08:03 .