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Toll‐like receptors 3, 7, and 9 in Juvenile nasopharyngeal angiofibroma
Author(s) -
Renkonen Suvi,
Cardell LarsOlaf,
Mattila Petri,
Lundberg Marie,
Haglund Caj,
Hagström Jaana,
Mäkitie Antti A.
Publication year - 2015
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12366
Subject(s) - juvenile nasopharyngeal angiofibroma , receptor , stromal cell , biology , immune system , innate immune system , angiofibroma , immunology , etiology , pathology , cancer research , medicine , anatomy , genetics , radiology
Juvenile nasopharyngeal angiofibroma ( JNA ) is a rare, benign tumor affecting adolescent males. The etiology of JNA as well as the causes determining the variable growth patterns of individual tumors remains unknown. Toll‐like receptors ( TLR s) are part of the innate immune response to microbes; by recognition of distinct features, they link to induction of pro‐inflammatory signaling pathways. We immunostained TLR 3, 7, and 9 in 27 JNA specimens of patients treated at the Helsinki University Central Hospital, Helsinki, Finland, during the years 1970–2009. Results: TLR 3, 7, and 9 expressions were found in stromal and endothelial cells of JNA, and their expression levels varied from negative to very strong positive. TLR 3 expression was found to have a significant correlation with the clinical stage of JNA . Conclusions: The present results propose a putative role of TLR s in the growth process of JNA .