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Targeted therapy in gastric cancer
Author(s) -
Thiel Alexandra,
Ristimäki Ari
Publication year - 2015
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12359
Subject(s) - medicine , ramucirumab , cetuximab , cancer , trastuzumab , oncology , targeted therapy , panitumumab , bevacizumab , everolimus , clinical trial , chemotherapy , colorectal cancer , breast cancer
Gastric cancer is often diagnosed at an advanced stage. Although chemotherapy prolongs survival and improves quality of life, the survival of gastric cancer patients with advanced disease is short. Thanks to recent insights into the molecular pathways involved in gastric carcinogenesis, new targeted treatment options have become available for gastric cancer patients. Trastuzumab, an antibody targeted to HER ‐2, was shown to improve survival of advanced gastric cancer patients harboring HER ‐2 overexpression due to gene amplification in their tumor cells, and is currently also explored in adjuvant and neoadjuvant settings. Another agent with promising results in clinical trials is ramucirumab, an antibody targeting VEGFR ‐2. No clear survival benefit, however, were experienced with agents targeting EGFR (cetuximab, panitumumab), VEGF ‐A (bevacizumab), or mTOR (everolimus). Drugs targeting c‐MET / HGF are currently under investigation in biomarker‐selected cohorts, with promising results in early clinical trials. This review will summarize the current status of targeted treatment options in gastric cancer.