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Gastric cancer in young vs old Romanian patients: immunoprofile with emphasis on maspin and mena protein reactivity
Author(s) -
Gurzu Simona,
Kadar Zoltan,
Sugimura Haruhiko,
Bara Tivadar,
Bara Tivadar,
Halmaciu Ioana,
Jung Ioan
Publication year - 2015
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12347
Subject(s) - maspin , medicine , cancer , vimentin , immunohistochemistry , cd31 , pathology , gastroenterology , oncology , metastasis
Increasing number of early‐onset gastric carcinomas ( GC s) and controversial results regarding the differences among young and older patients with this type of cancer are the reasons why correlation of clinicopathological factors with molecular markers is necessary. The aim of our study was to compare the demographic, clinical and immunohistochemical ( IHC ) aspects in Romanian patients with GC diagnosed below and above 45 years old. In 191 samples provided from patients with GC , the clinicopathological parameters were correlated with a panel of 15 antibodies: E‐cadherin, HER ‐2, VEGF , CD 31, CD 105, COX ‐2, maspin, bax, bcl‐2, p53, Ki67, MLH ‐1, MSH ‐2, mena protein and vimentin. Compared to the conventional cases, GC s diagnosed below 45 years old were more frequently located at the gastroesophageal junction and presented a higher percentage of lymph node metastases. The diffuse type E‐cadherin/mena/p53/Ki67/bax‐negative cases that displayed nuclear maspin positivity were also more frequently in younger patients. The intestinal type early‐onset GC s were the most angiogenic ones, the apoptotic rate being lower than in the intestinal type GC s of the aged. Compared to the conventional cases, in the early‐onset GC s the nuclear maspin‐mediated antiproliferative activity is more intense in diffuse type while the mena‐dependent tumor cell proliferation is more characteristic for intestinal type GC s.