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Interleukin 17A genetic variations and susceptibility to non‐small cell lung cancer
Author(s) -
Ma QinYun,
Chen Ji,
Wang ShaoHua,
Wu Ning,
Hao ZhenHua,
Chen XiaoFeng
Publication year - 2015
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12341
Subject(s) - lung cancer , biology , genetics , medicine , oncology
Lung cancer is the leading cause of cancer‐related death, in which non‐small cell lung cancer ( NSCLC ) is the most common type. Evidence have shown that interleukin 17 ( IL ‐17) greatly involves in human immune responses. In this study, we investigated the effect of IL ‐17 on NSCLC by examining the association between IL ‐17A genetic polymorphisms and the susceptibility to NSCLC . IL ‐17A ‐420A/G and IL ‐17A ‐73G/A polymorphisms were detected in 330 NSCLC patients and 382 healthy controls. We found that subjects carrying −73 GA genotype or AA genotype had 2.09‐fold or 2.52‐fold increased risk of NSCLC than those with −73 GG genotype [odds ratio ( OR ) = 2.09, 95% confidence interval ( CI ), 1.46 – 2.98, p < 0.001; OR = 2.52, 95% CI , 1.30–4.88, p = 0.005, respectively). However, the IL ‐17A ‐420A/G did not reveal any correlation with the cancer. Further investigation showed that prevalence of IL ‐17A −73 GA genotype and A allele were significantly increased in adenocarcinoma patients ( OR = 1.75, 95% CI , 1.08–2.86, p = 0.024, OR = 1.57, 95% CI , 1.09–2.28, p = 0.016, respectively). We also evaluated the effect of the polymorphisms on gene expression, and identified that peripheral blood mononuclear cells with IL ‐17A ‐73 GA and AA genotypes produced significantly higher level of IL ‐17 than the cells with IL ‐17A ‐73 GG genotype. Our results suggest that IL ‐17A ‐73G/A genetic variations may upregulate IL ‐17 expression and are associated with increased susceptibility to NSCLC .