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Description of the population structure and genetic diversity of tuberculosis in Estado de México, a low prevalence setting from Mexico
Author(s) -
ZentenoCuevas Roberto,
MendozaDamián Fabiola,
Muñoz Irving Cansino,
EncisoMoreno Leonor,
PérezNavarro Lucia Monserrat,
RamírezHernández Ma. Dolores,
VázquezMedina Karen,
WidroboGarcía Lorena,
Lauzardo Michael,
EncisoMoreno José Antonio
Publication year - 2015
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12312
Subject(s) - tuberculosis , genotype , biology , lineage (genetic) , genetic diversity , population , typing , drug resistance , mycobacterium tuberculosis , multiple drug resistance , veterinary medicine , demography , genetics , medicine , gene , pathology , sociology
In order to identify the genetic characteristics of the strains of mycobacteria circulating in the Estado de México, one of the states with the lowest prevalence of tuberculosis in Mexico, spoligotyping and 12‐loci MIRU ‐ VNTR typing were used to genotype tuberculosis clinical isolates. The average age of the 183 patients analyzed was 50 (± 17) years, drug resistance was noted in 57 (31%) and multidrug resistance in 22 (12%) individuals. The results from the isolates recovered showed that 80% were located in four major Euro‐American lineages: Haarlem (17%), LAM (15%), T (20%) and X (29%). Other lineages found in lower proportions were: EAI , S, Beijing, West African, Turkey, Vole and Bovis. Eighteen isolates were orphans. Only 57 isolates were grouped in nine clusters and the SIT 119 (X1) showed the highest number of members (23). The LAM lineage showed an increased risk for development of drug resistance ( RR =4, IC : 95%: 1.05–14.2, p = 0.03). Despite the important prevalence of four major lineages found and the diversity of strains circulating in the population, we found the presence of one of the largest populations of isolates clustered to the X lineage in a setting from a Latin American country.