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Personalized oncology: genomic screening in phase 1
Author(s) -
Tuxen Ida Viller,
Jønson Lars,
SantoniRugiu Eric,
Hasselby Jane Preuss,
Nielsen Finn Cilius,
Lassen Ulrik
Publication year - 2014
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12293
Subject(s) - personalized medicine , genomics , clinical trial , precision medicine , drug development , medicine , limiting , cancer , bioinformatics , computational biology , oncology , drug , biology , gene , genome , pharmacology , genetics , pathology , mechanical engineering , engineering
Improvements in cancer genomics and tumor biology have reinforced the evidence of cancer development driven by numerous genomic alterations. Advanced genomics technology can be used to characterize genomic alterations that potentially drive tumor growth. With the possibility of screening thousands of genes simultaneously, personalized molecular medicine has become an option. New treatments are being investigated in phase 1 trials around the world. Traditionally, the goal of phase 1 studies was to determine the optimal dose and assess dose‐limiting toxicity of a potential new experimental drug. Only a limited number of patients will benefit from the treatment. However, introducing genomic mapping to select patients for early clinical trials with targeted molecular therapy according to the genomic findings, may lead to a better outcome for the patient, an enrichment of phase 1 trials, and thereby accelerated drug development. The overall advantage is to determine which mutation profiles correlate with sensitivity or lack of resistance to specific targeted therapies. The utility and current limitations of genomic screening to guide selection to Phase 1 clinical trial will be discussed.