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Expression of group XIIA phospholipase A 2 in human digestive organs
Author(s) -
Peuravuori Heikki,
Kollanus Sinikka,
Nevalainen Timo J.
Publication year - 2014
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12280
Subject(s) - phospholipase a2 , gastrointestinal tract , cytoplasm , immunohistochemistry , biology , pancreas , medicine , pathology , endocrinology , enzyme , microbiology and biotechnology , biochemistry
Cellular distribution of group XIIA phospholipase A 2 ( GXIIA PLA 2 ) was studied in human digestive organs by immunohistochemistry. GXIIA PLA 2 protein was detected in epithelial cells of normal gastrointestinal tract, gallbladder and pancreatic acinar cells. The GXIIA PLA 2 protein was evenly distributed in the cytoplasm in contrast to secretory granular distribution of GIB PLA 2 and GIIA PLA 2 in pancreatic acinar cells and small intestinal Paneth cells respectively. Epithelial cells of intestinal glands in Crohn's disease and ulcerative colitis expressed abundant GXIIA PLA 2 , whereas inflammatory cells were devoid of the enzyme protein. Tumour cells in colonic adenomas and carcinomas and pancreatic ductogenic carcinomas expressed GXIIA PLA 2 protein at varying intensity levels. The putative functions of GXIIA PLA 2 remain to be investigated and its role in healthy and diseased digestive organs can only be speculated on at present.