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Evaluation of the serum levels of soluble IL ‐2 receptor and endothelin‐1 in children with Crimean‐Congo hemorrhagic fever
Author(s) -
Deveci Koksal,
Oflaz Mehmet Burhan,
Sancakdar Enver,
Uysal Elif Bilge,
Guven Ahmet Sami,
Kaya Ali,
Alkan Filiz,
Cevit Omer
Publication year - 2014
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12209
Subject(s) - crimean–congo hemorrhagic fever , endothelin receptor , pathogenesis , medicine , gastroenterology , endothelin 1 , immunology , disease , receptor
We aimed to assess the association between serum levels of soluble IL‐2 receptor ( sIL‐2r ) and endothelin‐1 and severe infection in children with Crimean‐Congo hemorrhagic fever (CCHF). Fifty‐two patients under 18 years of age with a laboratory‐ confirmed diagnosis of CCHF and 38 healthy controls were enrolled in the study. Patients were classified into two groups based on disease severity (severe group and non‐severe group). The sIL‐2r and endothelin‐1 levels were observed to be significantly higher in patients with severe CCHF compared with those with non‐severe CCHF and the control group (p < 0.05). In addition, those with non‐severe CCHF were also found to have a significantly higher sIL‐2r level relative to the control group (p < 0.001). Although there was a positive correlation between sIL‐2r and endothelin‐1 levels, serum levels of both sIL‐2r and endothelin‐1 were negatively correlated with the platelets count. In children with CCHF, serum levels of sIL‐2r and endothelin‐1 were increased, and this increase is related to the severity of the disease. In this study, we concluded through prognosis that serum levels of sIL‐2r and endothelin‐1 might be related, and that hemophagocytic lymphohistiocytosis and endothelial injury might contribute to a pathogenesis of the disease.