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Neuroendocrine carcinoma of the breast – a pilot study of a Danish population of 240 breast cancer patients
Author(s) -
Brask Julie Benedicte,
Talman MajLis Møller,
Wielenga Vera Timmermans
Publication year - 2014
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12197
Subject(s) - neuroendocrine carcinoma , medicine , incidence (geometry) , breast cancer , etiology , oncology , cancer , danish , carcinoma , breast carcinoma , population , pathology , lung cancer , lung , linguistics , philosophy , physics , environmental health , optics
Neuroendocrine carcinoma of the breast – a very recent diagnosis, which was not recognized by WHO until 2003 – has lately been the subject of increasing attention. It is defined as a primary breast cancer with morphologic features similar to other types of neuroendocrine tumors of the lung and gastrointestinal tract combined with positive neuroendocrine immunohistochemical markers. While much information has been gathered during the last decade, most studies suffer from poor statistics due to a low incidence, and there are still fundamental open questions regarding etiology and prognosis. Furthermore, apparent limitations of the WHO definition appear to influence diagnosis. Here, we present our own results obtained from 13 cases and furthermore review previous reports with particular reference to incidence, clinical, histological, and prognostic features.