Premium
Manganese superoxide dismutase plays an important role in the inflammatory process and predicts disease severity and activity in patients with ulcerative colitis
Author(s) -
Ikumoto Taro,
Hayashi Shinichi,
Tomita Shigeki,
Miwa Shigeharu,
Mitomi Hiroyuki,
Fujimori Takahiro,
Imura Johji
Publication year - 2014
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12192
Subject(s) - ulcerative colitis , lamina propria , exacerbation , pathogenesis , superoxide dismutase , pathology , medicine , colitis , inflammatory bowel disease , inflammation , immunohistochemistry , biopsy , endothelium , immunology , disease , oxidative stress , epithelium
The aim of this study was to investigate the expression pattern of manganese superoxide dismutase ( Mn SOD ) in relation to inflammatory factors in ulcerative colitis ( UC ) and characterize this enzyme as a newly identified biomarker potentially linked to disease pathogenesis of UC . Mn SOD expression was analyzed immunohistochemically in 48 formalin‐fixed and paraffin‐embedded specimens from patients with UC who had undergone endoscopical biopsy. Mn SOD expression was observed in vascular endothelium, macrophages, and polymorphonuclear leukocytes within lamina propria of inflamed mucosa. The patients who did not express Mn SOD tended to have stabilization of symptoms, but accompanied with status of inflammation. The Mn SOD expression pattern was strongly correlated with disease type. Mn SOD was expressed in polymorphonuclear leukocytes of all disease types, but cases of chronically counting and exacerbation type had particularly high frequency of immunopositive cells. Mn SOD expression in macrophages was frequently observed in cases of symptom remaining type. The cases with Mn SOD expression in the vascular endothelium showed a tendency to express in relapse‐remission and exacerbation of symptoms. Immunohistochemical evaluation for Mn SOD expression may be useful for predicting disease severity and activity in patients with UC .