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mi RNA in mycosis fungoides and skin inflammation
Author(s) -
Persson Jenny Liao
Publication year - 2013
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12186
Subject(s) - mycosis fungoides , cutaneous t cell lymphoma , lymphoma , medicine , inflammation , peripheral t cell lymphoma , immunology , rna , t cell , cancer research , pathology , dermatology , biology , immune system , gene , biochemistry
In this mini‐review, progress in our understanding of the link between mi RNA s and cytokines in inflammatory skin diseases is highlighted with focus on miR‐155 in mycosis fungoides ( MF ). MF is the most common variant of cutaneous T‐cell lymphoma ( CTCL ) and is characterized by malignant T‐cell proliferation in a chronic inflammatory environment in affected skin. Recent data show that miR‐155 is expressed in situ by both malignant and non‐malignant T cells, induced via the STAT 5 signal pathway and IL ‐2Rbeta/gamma cytokines, and thus suggest the importance of miR‐155 in malignant proliferation, clinical diagnosis, and prognosis in CTCL .
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