In vitro antimicrobial profile of U reaplasma urealyticum from genital tract of childbearing‐aged women in N orthern and S outhern I taly

U reaplasma urealyticum is an opportunistic pathogen during pregnancy and in newborns. Other clinical problems related to U . urealyticum infections are: no susceptibility to cell wall‐active drugs, limits of antibiotic treatment in pregnancy, and spread of antimicrobial resistance. In addition, the results of antimicrobial susceptibility against U . urealyticum from various countries are few and controversial. The antimicrobial susceptibility of U . urealyticum , isolated from cervical swabs and collected from outpatient childbearing‐aged women in I taly from 2009 to 2012, was performed against fluoroquinolones, macrolides, streptogramin and tetracyclines, using an available biochemical commercial kit and a specific solid culture medium, to improve the therapeutic management of these pathogenic agents. U reaplasma urealyticum was detected in 49.4% of samples, but significant bacterial load was revealed in 29.8%. In vitro tetracyclines showed the best activity against U . urealyticum , followed by streptogramin, macrolides, and fluoroquinolones.