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Overexpression of CDC 28 protein kinase regulatory subunit 1B confers an independent prognostic factor in nasopharyngeal carcinoma
Author(s) -
Lee SungWei,
Lin ChingYih,
Tian YuFeng,
Sun DingPing,
Lin LiChing,
Chen LiTzong,
Hsing ChungHsi,
Huang ChiangTing,
Hsu HanPing,
Huang HsuanYing,
Wu LiChing,
Li ChienFeng,
Shiue YowLing
Publication year - 2014
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12136
Subject(s) - nasopharyngeal carcinoma , medicine , cancer , oncology , metastasis , kinase , cancer research , pathology , biology , radiation therapy , microbiology and biotechnology
Data mining on public domain identified that CDC 28 protein kinase regulatory subunit 1B ( CKS 1B ) transcript was highly expressed in nasopharyngeal carcinoma ( NPC ). The expression of CKS 1B protein and its clinicopathological associations in patients with NPC were further evaluated. Immunoexpression of CKS 1B was retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. The correlations between CKS 1B immunoexpression levels and clinicopathological features, as well as patient survivals, were analyzed. High CKS 1B expression (49.2%) was correlated with the 7th American Joint Committee on Cancer ( AJCC ) stage (p = 0.014). In multivariate analyses, high CKS 1B expression emerged as an independent prognostic factor for worse disease‐specific survival (p < 0.001), metastasis‐free survival (p < 0.001), and local recurrence‐free survival (p = 0.001). High expression of CKS 1B is common and associated with adverse prognostic factors and might confer tumor aggressiveness through dysregulation of the cyclin‐dependent protein kinase (intrinsic regulatory activity) during cell cycle progression.