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Lower mannose‐binding lectin contributes to deleterious H1N1 2009 infection in children
Author(s) -
Gao Lailong,
Shang Shiqiang,
Zhang ChenMei,
Tong Meiqin,
Chen Yinghu
Publication year - 2014
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12111
Subject(s) - mannan binding lectin , antibody opsonization , immunology , innate immune system , complement system , antibody , virology , biology , lectin , lectin pathway , virus , influenza a virus , neutralization , immunity , immune system , alternative complement pathway , opsonin
Mannose‐binding lectin ( MBL ) has broad range of activity against viruses through the mechanisms of neutralization, opsonization, and complement activation. Prior studies have demonstrated that MBL inactivated the season's influenza virus. Due to the fact that children have no neutralizing antibody against H1N1 2009 virus, innate immunity may be crucial in the defense against influenza. Therefore, we studied whether MBL levels played a role in H1N1 2009 infection in children. In a prospective survey, we revealed that MBL levels in ICU influenza cases were significantly lower than in children with influenza from infection disease ward. MBL may be involved in innate immune responses to H1N1 2009 infection in children.