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Switch of cadherin expression as a diagnostic tool for Leydig cell tumours
Author(s) -
Bremmer F,
Schweyer S,
MartinOrtega M,
Hemmerlein B,
Strauss A,
Radzun HJ,
Behnes CL
Publication year - 2013
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12053
Subject(s) - leydig cell , cadherin , immunohistochemistry , hyperplasia , leydig cell tumor , cell , pathology , biology , pathogenesis , cancer research , medicine , endocrinology , luteinizing hormone , hormone , genetics
Leydig cell tumours comprise about 3% of all testicular tumours. The pathogenesis of Leydig cell tumours is still poorly understood. We investigated testis with Leydig cell hyperplasia and Leydig cell tumours for their expression pattern of P‐ and N‐cadherin. We could show a switch of expression of P‐ and N‐cadherin in Leydig cell hyperplasia and Leydig cell tumours in comparison with normal Leydig cells. Cadherins could be established as a new immunohistochemical marker for this testicular tumour entity; their possible role in tumour genesis will be discussed.