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Rotavirus genotype distribution in K yrgyzstan and K azakhstan, 2007–2009
Author(s) -
Vainio Kirsti,
Latipov Renat,
Utegenova Elmira,
Kasymbekova Kaliya,
Juraev Rivojiddin,
Asilova Mukhayyo,
Flem Elmira
Publication year - 2013
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/apm.12014
Subject(s) - rotavirus , genotype , acute gastroenteritis , rotavirus infections , virology , biology , genetics , virus , gene
This is the first study to present rotavirus genotype distribution in children admitted to a hospital with acute gastroenteritis in K yrgyzstan and K azakhstan from January 2007 through December 2009. In total, 858 rotavirus ELISA ‐positive samples were characterized by RT ‐ PCR , with a considerable geographical and seasonal variation in genotype distribution observed during the study. The globally common genotypes (G1P[8], G2P[4], G3P[8], G4P[8], G9P[8], G12P[8] and G12P[6]) accounted for 81.5–88.2% of the infections in K yrgyzstan and 72.3–79.3% of the infections in Kazakhstan. The predominant genotypes were G1P[8], G2P[4] and G3P[8]. G1P[8] was the dominating genotype in K yrgyzstan, detected in 51–64.7% of the samples. A similar predominance was not seen for G1P[8] in Kazakhstan, with a shift to G2P[4] predominance being seen in 2008. G9P[8] was a rare genotype in both countries, whereas G12 was detected in between 2.2% and 7.6% of the samples. The surveillance period was characterized by many co‐circulating genotypes, and eight unusual combinations (G1P[4], G2P[8], G2P[6], G3P[4], G9P[4], G12P[4], G9P[9] and G10P[4]) were detected. This study provides important baseline data on rotavirus genotypes in K yrgyzstan and K azakhstan in the pre‐vaccine era, and the results may indicate that the two licensed vaccines can be expected to prevent rotavirus disease in these countries.