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The regulation of gastric ghrelin secretion
Author(s) -
NunezSalces Maria,
Li Hui,
FeinleBisset Christine,
Young Richard L.,
Page Amanda J.
Publication year - 2021
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/apha.13588
Subject(s) - ghrelin , endocrinology , medicine , postprandial , context (archaeology) , orexigenic , bulimia nervosa , anorexia nervosa , gastroparesis , binge eating , obesity , gastric emptying , hormone , eating disorders , diabetes mellitus , biology , stomach , neuropeptide , receptor , neuropeptide y receptor , psychiatry , paleontology
Ghrelin is a gastric hormone with multiple physiological functions, including the stimulation of food intake and adiposity. It is well established that circulating ghrelin levels are closely associated with feeding patterns, rising strongly before a meal and lowering upon food intake. However, the mechanisms underlying the modulation of ghrelin secretion are not fully understood. The purpose of this review is to discuss current knowledge on the circadian oscillation of circulating ghrelin levels, the neural mechanisms stimulating fasting ghrelin levels and peripheral mechanisms modulating postprandial ghrelin levels. Furthermore, the therapeutic potential of targeting the ghrelin pathway is discussed in the context of the treatment of various metabolic disorders, including obesity, type 2 diabetes, diabetic gastroparesis and Prader‐Willi syndrome. Moreover, eating disorders including anorexia nervosa, bulimia nervosa and binge‐eating disorder are also discussed.