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Deregulated hypoxic response in myeloid cells: A model for high‐altitude pulmonary oedema (HAPE)
Author(s) -
Gojkovic Milos,
Darmasaputra Gabriella S.,
Veliça Pedro,
Rundqvist Helene,
Johnson Randall S.
Publication year - 2020
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/apha.13461
Subject(s) - medicine , high altitude pulmonary edema , pulmonary hypertension , hypoxic pulmonary vasoconstriction , myeloid , hypoxia (environmental) , ventricle , cardiology , pulmonary function testing , pulmonary edema , lung , pathology , chemistry , organic chemistry , oxygen
Abstract Aim High‐altitude pulmonary oedema (HAPE) is a non‐cardiogenic pulmonary oedema that can occur during rapid ascent to a high‐altitude environment. Classically, HAPE has been described as a condition resulting from a combination of pulmonary vasoconstriction and hypertension. Inflammation has been described as important in HAPE, although as a side effect of pulmonary oedema rather than as a causative factor. In this study, we aim to understand the role of hypoxic response in myeloid cells and its involvement in pathogenesis of HAPE. Methods We have generated a conditional deletion in mice of the von Hippel‐Lindau factor (VHL) in myeloid cells to determine the effect of a deregulated hypoxic response in pulmonary oedema. Results The deletion of VHL in pulmonary myeloid cells gave rise to pulmonary oedema, increased pulmonary vascular permeability and reduced performance during exertion. These changes were accompanied by reduced stroke volume in the left ventricle. Conclusion In this model, we show that a deregulated myeloid cell hypoxic response can trigger some of the most important symptoms of HAPE, and thus mice with a deletion of VHL in the myeloid lineage can function as a model of HAPE.