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Syndecan‐4, a model proteoglycan to study endothelial glycocalyx mechanosensing and signal transduction
Author(s) -
Berg Bernard M.
Publication year - 2020
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/apha.13410
Subject(s) - glycocalyx , syndecan 1 , microbiology and biotechnology , extracellular matrix , proteoglycan , mechanotransduction , cytoskeleton , endothelial stem cell , shear stress , biophysics , chemistry , biology , cell , mechanics , physics , biochemistry , in vitro
In the present issue of Acta Physiologica, Jiang, et al.1 tested how the endothelial glycocalyx transmits the blood flow shear stress to the cytoskeleton. In a series of large-scale molecular dynamics computational experiments the dynamics of the proteoglycan syndecan-4 force transmission is examined under varying conditions, i.e. blood flow velocity changes and proteoglycan sugar chain shedding.