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TRPM5 in the battle against diabetes and obesity
Author(s) -
Vennekens R.,
Mesuere M.,
Philippaert K.
Publication year - 2018
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/apha.12949
Subject(s) - taste , medicine , leptin , endocrinology , type 2 diabetes , diabetes mellitus , microbiology and biotechnology , biology , obesity , neuroscience
TRPM 5 is a non‐selective monovalent cation channel activated by increases in intracellular Ca 2+ . It has a distinct expression pattern: expression is detected in chemosensitive tissues from solitary chemosensory cells to the taste receptor cells and in pancreatic β ‐cells. The role of TRPM 5 has been investigated with the use of knockout mouse models. Trpm5 −/− mice have a lack of type II taste perception and show reduced glucose‐induced insulin secretion. Expression levels of TRPM 5 are reduced in obese, leptin‐signalling‐deficient mice, and mutations in TRPM 5 have been associated with type II diabetes and metabolic syndrome. In this review, we aim to give an overview of the activation, selectivity, modulation and physiological roles of TRPM 5.