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Unsung renal receptors: orphan G‐protein‐coupled receptors play essential roles in renal development and homeostasis
Author(s) -
Rajkumar P.,
Pluznick J. L.
Publication year - 2017
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/apha.12813
Subject(s) - g protein coupled receptor , homeostasis , receptor , function (biology) , biology , kidney , disease , computational biology , bioinformatics , microbiology and biotechnology , medicine , endocrinology , biochemistry
Recent studies have shown that orphan GPCR s of the GPR family are utilized as specialized chemosensors in various tissues to detect metabolites, and in turn to activate downstream pathways which regulate systemic homeostasis. These studies often find that such metabolites are generated by well‐known metabolic pathways, implying that known metabolites and chemicals may perform novel functions. In this review, we summarize recent findings highlighting the role of deorphanized GPR s in renal development and function. Understanding the role of these receptors is critical in gaining insights into mechanisms that regulate renal function both in health and in disease.