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Interactions of the orexin/hypocretin neurones and the histaminergic system
Author(s) -
Sundvik M.,
Panula P.
Publication year - 2015
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/apha.12432
Subject(s) - histaminergic , narcolepsy , orexin , neuroscience , wakefulness , orexin a , histamine , biology , medicine , neurology , endocrinology , neuropeptide , receptor , electroencephalography
Histaminergic and orexin/hypocretin systems are components in the brain wake‐promoting system. Both are affected in the sleep disorder narcolepsy, but the role of histamine in narcolepsy is unclear. The histaminergic neurones are activated by the orexin/hypocretin system in rodents, and the development of the orexin/hypocretin neurones is bidirectionally regulated by the histaminergic system in zebrafish. This review summarizes the current knowledge of the interactions of these two systems in normal and pathological conditions in humans and different animal models.